Causes of Hypogonadism

The causes of primary hypogonadism (Testicular failure) are:

  • Congenital disorders

– Androgen receptor/enzyme defects

– chromosomal defects, for example; Klinefelter’s syndrome

 

  • Physical damage to the testicles

– Surgical removal

– Chemotherapy

– Testicular trauma

 

  • Acquired

– Testosterone and/or anabolic steroid abuse

– Radiation exposure

 

  • Complications of illness

– E.g. Diabetes, renal failure, alcoholic liver disease

 

The causes of secondary hypogonadism are:

  • Congenital disorders

– Idiopathic hypo gonadotrophic hypogonadism (IHH)

– Kallmann’s syndrome

 

  • Pituitary disorders

– Hyperprolactinaemia

-Pituitary insufficiency

 

  • Acquired

– Steroid abuse

– Chronic Opiate use

– Obesity

 

  • Complications of illness

– Malnutrition

– Diabetes mellitus

– Anorexia Nervosa

– HIV/AIDS